on the correlation between aristolochic acid and hepatocellular carcinoma in aristolochic acids of Chinese Medicine, the state Food and Drug Administration spokesman said according to the Epidemiology large sample, the big data analysis, our country liver cancer patient mainly by the hepatitis B virus infection causes. Whether it is directly related to aristolochic acid, there is no direct and strong data support. The spokesman said aristolochic acid has a significant renal toxicity, which can cause impaired renal tubular function and even the risk of kidney cancer. In 2002, the World Health Organization (WHO) international Agency for Research on cancer classified aristolochic acid as a potentially carcinogenic substance, which was included in category I carcinogens in 2012. Since 2003, China has also adopted a series of risk control measures for medicinal herbs containing aristolochic acid and Chinese patent medicines, including the prohibition of the use of high content of aristolochic acid manshuriensis, wide prevention and Aristolochia; Adjust the use of medicinal herbs, clear safety warning, the horse bell belongs to the medicinal herbs of oral Chinese medicine in strict accordance with prescription drug management; The principles of treatment of medicinal herbs and other safety problems. A spokesman for the Food and Drug Administration said the measures had led to a significant drop in the number of cases of aristolochic acid-induced kidney damage and no direct report of kidney cancer. The medicinal herbs containing aristolochic acid have been used for thousands of years in our country. At present, included in the Chinese Pharmacopoeia, Ministry of Standards and local standards of medicinal materials of the horse Bell Department of Medicinal Herbs have 24 kinds, including the horse Bell is the medicinal herbs of Chinese Medicine oral preparations have 47 kinds, can be in the general administration of Food and drug website inquiries. “We remind patients that drugs should be used in strict accordance with the doctor’s prescriptions and instructions, to pay attention to the risk of kidney toxicity and carcinogenicity of aristolochic drugs,” said a spokesman for the F.D.A..